Venous Disease

A Progressive Medical Condition

An estimated 10% of adults suffer from venous disease, also known as chronic venous insufficiency (CVI).1,2 It is a progressive medical condition that worsens over time.

Many factors contribute to CVI, including:

  • Family history of CVI
  • Age over 50
  • Multiple pregnancies
  • Obesity
  • Long periods of standing or sitting

Vein Anatomy

Arteries carry oxygenated blood away from the heart to the tissues and organs.
Healthy veins carry deoxygenated blood from the tissues back to the heart and lungs.

Chronic Venous Insufficiency (CVI)

Healthy leg veins contain valves that open and close to assist the return of blood to the heart. Sometimes, the valves become damaged or diseased and can no longer close properly. As a result, blood can leak back through the valve, or reflux, and pool in the lower leg veins. This can lead to chronic venous insufficiency (CVI).

Signs and Symptoms

Signs and symptoms of CVI vary. Some patients may have symptoms but few to no visible signs of CVI.

Common signs and symptoms in the lower legs include:

  • Varicose veins or spider veins
  • Heaviness, aching, tightness or fatigue
  • Discomfort, pain or swelling
  • Restlessness or cramping
  • Numbness or itching
  • Skin texture or color changes
  • Ulcer or poor healing wound

Without treatment, signs and symptoms may worsen.

Spider Veins
Varicose Veins
Leg Swelling
Skin Changes
Leg Ulcers

1. Gloviczki P, et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011 May;53(5 Suppl):2S-48S.
2. Evans CJ, et al. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Community Health 1999;53:149–53.